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Child Atopic Risk and Parental Allergen- Specific IgE |
Canfield et al examined the parent-child associations of total and specific (dust mite, cockroach, mouse or cat) IgE in serum specimens from 161 families (mother, father, 4 year old child) from New York City neighborhoods with high asthma prevalence. Children were not selected on the basis of allergic symptoms; however, 27% were sensitized to at least 1 allergen assessed, a higher prevalence than reported in national data for this age. Total IgE was higher among boys than girls (P = .03) and among older (≥48 months) than younger (≤ 48 months) children (P = .2; ns). Boys and older children’s total IgE was correlated with the total IgE of both parents. Total IgE associations Improved slightly with adjustment for ethnicity and tobacco smoke exposure. With respect to seroatopy, number of sensitizations (0-4), and the sum of the allergen-specific, IgEs, associations between mother and child strongly outweighed those between father and child, overall and within age and sex strata. Dust mite sensitization among mothers (but not fathers) was highly predictive of child sensitization to each of the 4 allergens examined. Mothers' specific IgE to locally relevant inhalant allergens represents a potential indicator of their child's atopic risk distinct from total IgE.
"Total and Specific IgE Associations between New York City Head Start Children and their Parents" |
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